Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) (CAT#: TAB-611CT)
This product is a recombinant humanized antibody that specifically binds to human transferrin receptor (TfR) and primate TfR. The antibody was purified by affinity chromatography.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
ELISA
Figure 1 Anti-Human TfR Antibody (TAB-611CT) in ELISA
ELISA analysis of TAB-611CT was performed by coating with Cynomolgus Transferrin Receptor Protein and Human Transferrin Receptor Protein.
Red line: Recombinant Cynomolgus Transferrin Receptor Protein (His Tag)
Blue line: Recombinant Human Transferrin Receptor Protein (His Tag)
WB
Figure 2 Anti-Human TfR Antibody (TAB-611CT) in WB
Western blot analysis of TAB-611CT was performed with Recombinant Human Transferrin Receptor Protein.
Lane 1: Blank
Lane 2: Blank
Lane 3: 40ng Recombinant Cynomolgus Transferrin Receptor Protein
Lane 4: 40ng Recombinant Cynomolgus Transferrin Receptor Protein
Lane 5: Marker
Lane 6: 40ng Recombinant Human Transferrin Receptor Protein
Lane 7: 80ng Recombinant Human Transferrin Receptor Protein
Lane 8: 160ng Recombinant Human Transferrin Receptor Protein
Lane 9: 320ng Recombinant Human Transferrin Receptor Protein
Lane 10: Blank
Specifications
- Host Species
- Humanized
- Type
- Humanized IgG
- Specificity
- Human
- Species Reactivity
- Human, Cynomolgus monkey
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90; CD71); anti-CD71
- Gene ID
- 7037
- UniProt ID
- P02786
Related Resources
Desjardins, Cody A., et al. "Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice." Nucleic acids research 50.20 (2022): 11401-11414. https://doi.org/10.1093/nar/gkac641
This study focuses on developing an enhanced delivery mechanism for phosphorodiamidate morpholino oligomers (PMO) to treat Duchenne muscular dystrophy (DMD). Traditional therapies aim to induce exon skipping in the dystrophin pre-mRNA to produce a functional dystrophin protein. However, these therapies often face challenges in effectively delivering PMO to cardiac and skeletal muscles. To address this, the researchers developed the FORCE™ platform, which utilizes a Fab fragment targeting the transferrin receptor 1 (TfR1) conjugated to the PMO. This approach demonstrated significantly improved muscle delivery, achieving dose-dependent and robust exon skipping and sustained dystrophin restoration in mdx mice, a model for DMD.
Creative Biolabs provided several key products for this study, significantly contributing to its success. They supplied the human monoclonal antibody targeting human TfR1 (15G11, Cat# TAB-611CT), which was essential for validating the specificity and efficacy of the FORCE™ conjugate. Additionally, Creative Biolabs provided other critical reagents and antibodies that facilitated the extensive biochemical and molecular analyses conducted in the study. These contributions were crucial in enabling the detailed examination of the FORCE™ platform's ability to enhance PMO delivery and restore dystrophin expression, thereby demonstrating its potential as an effective treatment approach for DMD.
More Infomation
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TFRC"
Select a product category from the dropdown menu below to view related products.
Please select product type
ScFv Antibody Products
Immunotoxin Products
Mouse Antibody Products
Human Antibody Products
Humanized Antibody Products
IgM Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
MHC Tetramer Products for Cancer
IgG Antibody Products
Fab Antibody Products
Antibody Magnetic Beads
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1176z-S(P) | Recombinant Anti-Human TFRC Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0238-YJ-S(P) | Rat Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0238-YJ-S(P)) | IHC, FC, WB, FuncS | Rat scFv |
| HPAB-0239-YJ-S(P) | Rat Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0239-YJ-S(P)) | IHC, FC, WB, FuncS | Rat scFv |
| HPAB-0240-YJ-S(P) | Rat Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0240-YJ-S(P)) | IHC, FC, WB, FuncS | Rat scFv |
| HPAB-AP469-YC-S(P) | Human Anti-TFRC Recombinant Antibody (clone c5D7); scFv Fragment | FC, WB, Cyt, Inhib, FuncS | Mouse scFv |
Customer Reviews and Q&As
Customer Review
Q&As
Jessica Green
Great for TFRC Detection
Great for TFRC Detection
The Anti-TFRC Recombinant Antibody has been excellent for our TFRC detection assays. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
18.Jun,23
Michael Evans
Effective in Immunoassays
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for TFRC is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
23.Nov,22
Sarah Davis
Consistent and Reliable
Consistent and Reliable
This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for TFRC have been particularly beneficial.
12.May,21
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-611CT, RRID: AB_3111977)
Copy citation
Popular products with customers
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: ELISA
Application: FC, FRET, Internalization
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Inhib
Application: FC
Application: ELISA, Inhib, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
