Humanized Anti-TFRC Recombinant Antibody (TAB-611CT)

Customer Review

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Jessica Green
18.Jun,23

Great for TFRC Detection

The Anti-TFRC Recombinant Antibody has been excellent for our TFRC detection assays. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

Michael Evans
23.Nov,22

Effective in Immunoassays

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for TFRC is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

Sarah Davis
12.May,21

Consistent and Reliable

This antibody has proven to be consistent and reliable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for TFRC have been particularly beneficial.

Q&As

1. Is the anti-TFRC recombinant antibody suitable for use in Western blotting?

   A: Yes, the anti-TFRC recombinant antibody (TAB-611CT) is suitable for use in Western blotting. It provides specific binding to TFRC, allowing for reliable detection in Western blot assays.

2. What are the storage recommendations for the anti-TFRC recombinant antibody?

   A: The recommended storage condition for the anti-TFRC recombinant antibody (TAB-611CT) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.

3. Can the anti-TFRC recombinant antibody be used in immunoprecipitation assays?

   A: Yes, the anti-TFRC recombinant antibody (TAB-611CT) can be used in immunoprecipitation assays. It provides specific binding to TFRC, enabling the successful precipitation of the target protein from complex mixtures.

4. Is the anti-TFRC recombinant antibody effective in ELISA applications?

   A: Yes, the anti-TFRC recombinant antibody (TAB-611CT) is effective in ELISA applications. It has been validated for use in such assays and provides reliable detection of TFRC.

5. What is the optimal dilution for using the anti-TFRC recombinant antibody in immunofluorescence?

   A: The optimal dilution for using the anti-TFRC recombinant antibody (TAB-611CT) in immunofluorescence is typically 1:100 to 1:500. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Desjardins, Cody A., et al. "Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice." Nucleic acids research 50.20 (2022): 11401-11414. https://doi.org/10.1093/nar/gkac641
   This study focuses on developing an enhanced delivery mechanism for phosphorodiamidate morpholino oligomers (PMO) to treat Duchenne muscular dystrophy (DMD). Traditional therapies aim to induce exon skipping in the dystrophin pre-mRNA to produce a functional dystrophin protein. However, these therapies often face challenges in effectively delivering PMO to cardiac and skeletal muscles. To address this, the researchers developed the FORCE™ platform, which utilizes a Fab fragment targeting the transferrin receptor 1 (TfR1) conjugated to the PMO. This approach demonstrated significantly improved muscle delivery, achieving dose-dependent and robust exon skipping and sustained dystrophin restoration in mdx mice, a model for DMD.
   Creative Biolabs provided several key products for this study, significantly contributing to its success. They supplied the human monoclonal antibody targeting human TfR1 (15G11, Cat# TAB-611CT), which was essential for validating the specificity and efficacy of the FORCE™ conjugate. Additionally, Creative Biolabs provided other critical reagents and antibodies that facilitated the extensive biochemical and molecular analyses conducted in the study. These contributions were crucial in enabling the detailed examination of the FORCE™ platform's ability to enhance PMO delivery and restore dystrophin expression, thereby demonstrating its potential as an effective treatment approach for DMD.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-611CT, RRID: AB_3111977)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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